Production of the Blood Pressure Lowing Peptides from Brown Alga （ Undaria pinnatifida ）     

Sato Minoru Oba Takashi Hosokawa Takao Yamaguchi Toshiyasu Nakano Toshiki Saito Tadao Muramoto Koji Kahara T akashi Funayama Katsura Kobayashi Akio Nakano Takahisa 《中国海洋大学学报(英文版)》2005,4(3):209-213

Brown alga （ Undaria pinnatifida） was treated with alginate lyase and hydrolyzed using 17 kinds of proteases and the inhibitory activity of the hydrolysates for the angiotensin-I-converting enzyme （ACE） was measured. Four hydrolysates with potent ACE-inhibitory activity were administered singly and orally to spontaneously hypertensive rats （SHRs）. The systolic blood pressure of SHRs decreases significantly after single oral administration of the brown alga hydrolysates by pro- tease S ＇ Amano＇ （from Bacillus stearothermophilus） at the concentration of 10 （mg protein） （kg body weight）^ - 1. In the 17 weeks of feeding experiment, 7-week-old SHRs were fed standard diet supplemented with the brown alga hydrolysates for 10 weeks. In SHRs fed 1.0 and 0.1% brown alga hydrolysates, elevating of systolic bloodpressure was significantly suppressed for 7 weeks. To elucidate the active components, the brown alga hydrolysates were fractionated by 1-butanol extraction and HPLC on a reverse-phase column. Seven kinds of ACE-inhibitory peptides were isolated and identified by amino acid composition analysis, sequence analysis, and LC-MS with the results Val-Tyr, Ile-Tyr, Ala-Trp, Phe-Tyr, Val-Trp, Ile-Trp, and Leu-Trp. Each peptide was determined to have an antihypertensive effect after a single oral administration in SHRs. The brown alga hydrolysates were also confirmed to decrease the blood pressure in humans.  相似文献   

Statistics of Wind and Waves off Tsuyazaki, Fukuoka, in the Eastern Tsushima Strait     

Akira Masuda  Tadao Kusaba  Kenji Marubayashi  Michiyoshi Ishibashi 《Journal of Oceanography》1999,55(2):289-305

The variability of the sea surface wind and wind waves in the coastal area of the Eastern Tsushima Strait was investigated based on the hourly data from 1990 to 1997 obtained at a station 2 km off Tsuyazaki, Fukuoka. The annual mean wind speed was 4.84 m s⁻¹, with strong northwesterly monsoon in winter and weak southwesterly wind in summer. Significant wave heights and wave periods showed similar sinusoidal seasonal cycles around their annual means of 0.608 m and 4.77 s, respectively. The seasonal variability relative to the annual mean is maximum for wave heights, medium for wind speeds, and minimum for wave periods. Significant wave heights off Tsuyazaki turned out to be bounded by a criterion, which is proportional to the square of the significant wave period corresponding to a constant steepness, irrespective of the season or the wind speed. For terms shorter than a month, the significant wave height and the wave period were found to have the same spectral form as the inshore wind velocity: white for frequencies less than 0.2 day⁻¹ and proportional to the frequency to the −5/3 power for higher frequencies, where the latter corresponds to the inertial subrange of turbulence. The spectral levels of wave heights and wave periods in that inertial range were also correlated with those of the inshore wind velocity, though the scatter was large. This revised version was published online in August 2006 with corrections to the Cover Date.  相似文献   

Wave motions around different submerged structures   总被引：2，自引：1，他引：1  

Gao Xueping  Inouchi Kunimitsu  Kakinuma Tadao 《海洋学报(英文版)》1998,17(3):363-374

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Effects of structural walls on the elastic–plastic earthquake responses of frame–wall buildings     

Xhafer Kongoli  Tadao Minami  Yuki Sakai 《地震工程与结构动力学》1999,28(5):479-500

Effects of structural walls on the elastic–plastic earthquake response of short- to medium-height reinforced concrete buildings were investigated. The analytical model consists of independent lumped mass systems representing walls and frames connected at each floor. The wall structure undergoes flexural as well as shear deformation and fails in shear at relatively small story drifts, the frames deforming only in shear. As a measure of structural damage, the ductility factor responses of frame structures were calculated for different combinations of base shear coefficients for the frames and walls. In buildings with relatively weak frames, the installation of structural walls did not improve the large plastic response of the frames up to the point where the walls were unfailed in shear and the ductility factors of the frame structure were suddenly reduced to a very small number. For relatively strong frames, however, the response displacements decreased gradually as the number of walls increased, whether or not the walls failed. Empirical formulas for the required base shear coefficients of the walls and frames which gave a target ductility factor response also were derived for two particular groups of accelerograms. These equations should be of practical use in designing frame-wall type buildings and in retrofitting damaged buildings. Copyright © 1999 John Wiley & Sons, Ltd.  相似文献   

Coastal vulnerability assessment of the future sea level rise in Udupi coastal zone of Karnataka state, west coast of India   总被引：1，自引：0，他引：1  

G.S. Dwarakish  S.A. Vinay  Usha Natesan  Toshiyuki Asano  Taro Kakinuma  Katta Venkataramana  B. Jagadeesha Pai  M.K. Babita   《Ocean & Coastal Management》2009,52(9):467-478

Udupi coast in Karnataka state, along the west coast of India, selected as a study area, is well known for sandy beaches, aquaculture ponds, lush greenery, temples and major and minor industries. It lies between 13°00′00″–13°45′00″ north latitudes and 74°47′30″–74°30′00″ east longitudes, the length of the coastline is 95 km, and is oriented along the NNW–SSE direction. It is vulnerable to accelerated sea level rise (SLR) due to its low topography and its high ecological and touristy value. The present study has been carried out with a view to calculate the coastal vulnerability index (CVI) to know the high and low vulnerable areas and area of inundation due to future SLR, and land loss due to coastal erosion. Both conventional and remotely sensed data were used and analysed through the modelling technique and by using ERDAS Imagine and geographical information system software. The rate of erosion was 0.6018 km²/yr during 2000–2006 and around 46 km of the total 95 km stretch is under critical erosion. Out of the 95 km stretch coastline, 59% is at very high risk, 7% high, 4% moderate and 30% in the low vulnerable category, due to SLR. Results of the inundation analysis indicate that 42.19 km² and 372.08 km² of the land area will be submerged by flooding at 1 m and 10 m inundation levels. The most severely affected sectors are expected to be the residential and recreational areas, agricultural land, and the natural ecosystem. As this coast is planned for future coastal developmental activities, measures such as building regulation, urban growth planning, development of an integrated coastal zone management, strict enforcement of the Coastal Regulation Zone (CRZ) Act 1991, monitoring of impacts and further research in this regard are recommended for the study area.  相似文献   

Thermochronology and the three-dimensional cooling pattern of a granitic pluton: an example from the Toki granite,Central Japan     

Takashi Yuguchi  Kenji Amano  Tadahiko Tsuruta  Tohru Danhara  Tadao Nishiyama 《Contributions to Mineralogy and Petrology》2011,162(5):1063-1077

The three-dimensional spatial variations in the cooling pattern of the Toki granitic body, a zoned pluton in Central Japan, have been evaluated quantitatively by thermochronology using cooling age determination based on the different closure temperatures for target mineral species. The Toki granite has hornblende K–Ar ages of about 74.3 ± 3.7 Ma (N = 2; closure temperature of 510 ± 25°C), biotite K–Ar ages of 78.5 ± 3.9 to 59.7 ± 1.5 Ma (N = 33; 300 ± 50°C), and zircon fission-track ages of 75.6 ± 3.3 to 52.8 ± 2.6 Ma (N = 44; 240 ± 50°C). The spatial variation in the biotite K–Ar age is similar to that in the zircon fission-track age in samples collected from 11 boreholes and seven outcrop sites in the Toki granite, indicating that cooling was effectively from the roof and also from the northwest margin. This cooling pattern shows a strong correlation with the Alumina Saturation Index (ASI) distribution of the body. Larger ASI values correspond to earlier and more rapid cooling after emplacement and smaller value to slower cooling. Toki granite was effectively cooled from the peraluminous regions where assimilation of country sedimentary rock was most extensive.  相似文献   

Three-dimensional properties of interplanetary disturbances in 1978–1981     

Takashi Watanabe  Takakiyo Kakinuma 《Astrophysics and Space Science》1986,118(1-2):153-157

This paper presents the average three-dimensional configuration of solar flare- or disappearing filament-associated interplanetary disturbances on the basis of IPS (interplanetary scintillation) and spacecraft observations in 1978–1981. The angular distribution of the propagation speed at 1 AU is largely isotropic over the range of 110° in solar longitude centered at the normal of the solar source. In the latitudinal direction, the characteristic angular extent is about 60°. Thus the three-dimensional shape of an interplanetary disturbance can be approximated by a half of an ellipsoid having an axial ratio of about 1.8.Paper presented at the IAU Third Asian-Pacific Regional Meeting, held in Kyoto, Japan, between 30 September–6 October, 1984.  相似文献   

Degradation of crude oils byPseudomonas sp. in enriched seawater medium     

Akihiko Murakami  Kazunobu Suzuki  Akiko Yamane  Tadao Kusama 《Journal of Oceanography》1985,41(5):337-344

Microbial degradation of five crude oils such as Arabian light, Berri, Murban, Khafji and Minas crude oil by a pure bacterial strain,Pseudomonas sp. isolated from the sea water sampled at Kawasaki Harbor in Tokyo Bay, was studied experimentally in the enriched seawater medium.The degradation of crude oils was determined in total residual oil and in four fractions of saturated, aromatics, asphaltene and column residue by use of the column chromatography with activated alumina.The saturated fraction was shown to be most biodegradable. The aromatics followed for all five crude oils examined and the asphaltene was biodegradable to some extent. The column residue was not apparently degraded byPseudomonas sp. within 30 days. Each of Arabian light, Berri or Murban crude oil was degraded from 59 to 63.5 %, Khafji crude oil 49 % and Minas crude oil, solid at room temperature, only 33 %. Degradation rate of the five crude oils was determined to be in a range from 2.88 to 17.3 mg-oil 1^–1 hr^–1 or from 6.0×10^–12 to 1.56×10^–10 mg-oil cell^–1 hr^–1. Relative degradation ofn-paraffins of different carbon numbers in the saturated fraction was found to be similar regardless of carbon number for the five crude oils.  相似文献   

Determination of reaction kinetics using grain size: An application for metamorphic zircon growth          下载免费PDF全文

Kazuhiro Miyazaki  Yasushi Mori  Tadao Nishiyama  Kenshi Suga  Miki Shigeno 《地学学报》2018,30(2):162-168

The reaction kinetics of metamorphic minerals can be subdivided into interface‐ and diffusion‐controlled kinetics. The discrimination of reaction kinetics is crucial for estimating reaction rates. Here, we propose a new and simple method for discriminating reaction kinetics. This method requires measuring only the initial and final grain sizes during growth. The reaction kinetics is inferred from different plotted arrays of initial vs. final grain sizes after the mineral growth. Using metamorphic zircon, we take detrital core sizes as the initial sizes and post‐metamorphic grain sizes as the final sizes. The application of the method to the subduction‐related high‐pressure Nagasaki metamorphic complex in Japan shows that this metamorphic zircon grew under interface‐controlled kinetics even at the relatively low temperature of 440°C. This method is potentially applicable to other minerals that have time‐markers, such as chemical zoning or internal structures that are captured at a given point in time during growth.  相似文献   

Chemical mass balance in a reaction zone between serpentinite and metapelites in the Nishisonogi metamorphic rocks, Kyushu, Japan: Implications for devolatilization   总被引：1，自引：0，他引：1  

Yasushi  Mori  Tadao  Nishiyama  Takeru  Yanagi 《Island Arc》2007,16(1):28-39

Abstract   Reaction zones of 0.5–10.0 m thick are commonly observed between serpentinite and pelitic schist in the Nishisonogi metamorphic rocks, Kyushu, Japan. Each reaction zone consists of almost monomineralic or bimineralic layers of talc + carbonates, actinolite (or carbonates + quartz), chlorite, muscovite and albite from serpentinite to pelitic schist. Magnesite + quartz veins extend into the serpentinite from the talc + carbonates layer, while dolomite veins extend into the pelitic schist from the muscovite layer. These veins are filled by subhedral minerals with oriented growth features. Primary fluid inclusions yield the same homogenization temperatures (145–150°C) both in the reaction zone and in the veins, suggesting their simultaneous formation. Mass-balance calculations using the isocon method indicate that SiO₂, MgO, H₂O and K₂O are depleted in the reaction zone relative to the protoliths. These components were probably extracted from the reaction zone as fluids during the formation of the reaction zone.  相似文献